Medical historians describe physicians who claim that diabetes mellitus is curable as quacks. Let the dog quack because pre-diabetes and early diabetes are reversible, at least for a period of years. Dr. Holt has expressed his passionate thoughts about the combat against the metabolic Syndrome X. If a healthcare consumer cannot receive information on the metabolic Syndrome X from their physician or health food store advisor, they should vote with their feet. There are 70 million Americans who suffer from the variable combination of being overweight, having high blood pressure or high blood cholesterol or linked by underlying resistance to the hormone insulin. Dr. Holt has made a constant challenge to physicians and healthcare givers about their understanding of the role of insulin resistance in propagation of obesity, high blood pressure, high blood cholesterol, depression of immunity, cancer, inflammation, menstrual irregularities and infertility – to name a few disorders.